SCHEMBL28344178

SCHEMBL28344178

CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)NC(CCCCNC(=O)OCc2ccccc2)C(=O)c2nc3ccccc3s2)C1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 1/20 0.60
ITGA2B P08514 1/20 0.60
ABCB1 P08183 1/20 0.47
MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17646351 1.00 ITGB3 (0.60) ITGB3ITGA2BABCB1MAPT
SCHEMBL17646384 1.00 ITGB3 (0.60) ITGB3ITGA2BABCB1MAPT
SCHEMBL22150089 1.00 ITGB3 (0.60) ITGB3ITGA2BABCB1MAPT
SCHEMBL17646271 0.91 ITGB3 (0.54) ITGB3ITGA2B
SCHEMBL17672350 0.91 ITGB3 (0.54) ITGB3ITGA2B
SCHEMBL17646314 0.91 ITGB3 (0.54) ITGB3ITGA2B
SCHEMBL17646340 0.91 ITGB3 (0.54) ITGB3ITGA2B
SCHEMBL17646238 0.89 HDAC3 (0.50) ITGB3ITGA2B
SCHEMBL22150083 0.89 HDAC3 (0.50) ITGB3ITGA2B
SCHEMBL17672345 0.89 ITGB3 (0.53) ITGB3ITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111349053-A Inhibitors of lysine porphyromonas gingivalis protease 库特克希米公司 2020-06-30 CN disclosed
CN-107108468-B Inhibitors of lysine porphyromonas gingivalis protease 库特克希米公司 2020-01-03 CN disclosed