Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17672350 | 1.00 | ITGB3 (0.54) | ITGB3ITGA2BHDAC3HDAC4HDAC1 | |
| SCHEMBL17646340 | 1.00 | ITGB3 (0.54) | ITGB3ITGA2BHDAC3HDAC4HDAC1 | |
| SCHEMBL17646314 | 1.00 | ITGB3 (0.54) | ITGB3ITGA2BHDAC3HDAC4HDAC1 | |
| SCHEMBL22150089 | 0.91 | ITGB3 (0.60) | ITGB3ITGA2B | |
| SCHEMBL17646384 | 0.91 | ITGB3 (0.60) | ITGB3ITGA2B | |
| SCHEMBL17646351 | 0.91 | ITGB3 (0.60) | ITGB3ITGA2B | |
| SCHEMBL28344178 | 0.91 | ITGB3 (0.60) | ITGB3ITGA2B | |
| SCHEMBL17646380 | 0.91 | ITGB3 (0.52) | ITGB3ITGA2BF2 | |
| SCHEMBL17646283 | 0.91 | ITGB3 (0.52) | ITGB3ITGA2BF2 | |
| SCHEMBL17661732 | 0.91 | ITGB3 (0.52) | ITGB3ITGA2BF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332464-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2022-05-17 | — | — | US | disclosed |
| US-20210017167-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2021-01-21 | — | — | US | disclosed |
| EP-3204352-B1 | INHIBITORS OF LYSINE GINGIPAIN | CORTEXYME INC (US) | 2020-07-01 | — | — | EP | disclosed |
| US-10676470-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2020-06-09 | — | — | US | disclosed |
| US-20190322659-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2019-10-24 | — | — | US | disclosed |
| US-10301301-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2019-05-28 | — | — | US | disclosed |
| US-20180346460-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-12-06 | — | — | US | disclosed |
| US-9988375-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2018-06-05 | — | — | US | disclosed |
| US-9988375-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170349537-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170349537-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2017-12-07 | — | — | US | disclosed |
| US-9758473-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2017-09-12 | — | — | US | disclosed |
| US-9758473-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2017-09-12 | — | — | US | disclosed |
| US-9758473-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2017-09-12 | — | — | US | disclosed |
| EP-3204352-A2 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016057413-A2 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016057413-A2 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20160096830-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2016-04-07 | — | — | US | disclosed |
| US-20160096830-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2016-04-07 | — | — | US | disclosed |
| US-20160096830-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2016-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346460-A1 | INHIBITORS OF LYSINE GINGIPAIN | ENPEP, PHYKPL, PREP | ITGB3 3890/4885ITGA2B 2880/4885HDAC3 1067/4885 |
| US-20190322659-A1 | INHIBITORS OF LYSINE GINGIPAIN | ENPEP, PHYKPL, PREP | ITGB3 3890/4885ITGA2B 2880/4885HDAC3 1067/4885 |
| US-20210017167-A1 | INHIBITORS OF LYSINE GINGIPAIN | ENPEP, PHYKPL, PREP | ITGB3 3890/4885ITGA2B 2880/4885HDAC3 1067/4885 |
| US-10676470-B2 | Inhibitors of lysine gingipain | ENPEP, PHYKPL, PREP | ITGB3 3890/4885ITGA2B 2880/4885HDAC3 1067/4885 |
| US-20170349537-A1 | INHIBITORS OF LYSINE GINGIPAIN | ENPEP, PHYKPL, PREP | ITGB3 3890/4885ITGA2B 2880/4885HDAC3 1067/4885 |
| US-20160096830-A1 | INHIBITORS OF LYSINE GINGIPAIN | ENPEP, PHYKPL, PREP | ITGB3 3890/4885ITGA2B 2880/4885HDAC3 1067/4885 |
| US-11332464-B2 | Inhibitors of lysine gingipain | ENPEP, PHYKPL, PREP | ITGB3 3890/4885ITGA2B 2880/4885HDAC3 1067/4885 |
| US-10301301-B2 | Inhibitors of lysine gingipain | ENPEP, PHYKPL, PREP | ITGB3 3890/4885ITGA2B 2880/4885HDAC3 1067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.