Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.86 |
| ▸ | LMNA | P02545 | 3/20 | 0.86 |
| ▸ | MAPT | P10636 | 2/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.86 |
| ▸ | THPO | P40225 | 2/20 | 0.86 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.86 |
| ▸ | GMNN | O75496 | 1/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.86 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.86 |
| ▸ | TSHR | P16473 | 1/20 | 0.86 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.86 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.86 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.86 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10324375 | 0.94 | SMN1; SMN2 (0.86) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL17803700 | 0.93 | SMN1; SMN2 (0.89) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL28272037 | 0.93 | SMN1; SMN2 (0.94) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL5318105 | 0.93 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL4308 | 0.93 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL29039570 | 0.92 | SMN1; SMN2 (0.78) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL28694332 | 0.92 | ALDH1A1 (0.82) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL28942852 | 0.92 | SMN1; SMN2 (0.91) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL28743193 | 0.92 | SMN1; SMN2 (0.91) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT | |
| Chlorambucil SCHEMBL23753952 | 0.91 | SMN1; SMN2 (0.97) | SMN1; SMN2ALDH1A1HIF1ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115581776-A | Controllable catalytic oncolytic complex capable of activating tumor immunity | 温州医科大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-115429877-A | TIGIT binding agents and uses thereof | 梅里奥生物制药第五有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-109071620-B | TIGIT binding agents and uses thereof | 梅里奥生物制药第五有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-110662552-A | Methods of cancer treatment comprising TIGIT binding agents | 昂科梅德制药有限公司 | 2020-01-07 | — | — | CN | disclosed |