Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.94 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.94 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.81 |
| ▸ | MEN1 | O00255 | 4/20 | 0.81 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15798361 | 0.87 | SMN1; SMN2 (0.80) | RAB9ASMN1; SMN2NPC1TP53PSMD14 | |
| SCHEMBL6819048 | 0.84 | RAB9A (0.72) | RAB9ASMN1; SMN2NPC1TP53PSMD14 | |
| SCHEMBL6633618 | 0.83 | KMT2A (0.89) | RAB9ASMN1; SMN2NPC1TP53PSMD14 | |
| SCHEMBL15056399 | 0.83 | RAB9A (0.75) | RAB9ASMN1; SMN2NPC1TP53PSMD14 | |
| SCHEMBL6816533 | 0.82 | SMN1; SMN2 (0.84) | RAB9ASMN1; SMN2NPC1TP53PSMD14 | |
| SCHEMBL8434936 | 0.81 | RAB9A (0.75) | RAB9ASMN1; SMN2NPC1TP53PSMD14 | |
| SCHEMBL24711259 | 0.81 | SMN1; SMN2 (1.00) | RAB9ASMN1; SMN2NPC1TP53PSMD14 | |
| SCHEMBL1846669 | 0.81 | RAB9A (0.83) | RAB9ASMN1; SMN2NPC1TP53KMT2A | |
| SCHEMBL22823075 | 0.81 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1TP53KMT2A | |
| SCHEMBL19994485 | 0.81 | KMT2A (0.71) | RAB9ASMN1; SMN2NPC1TP53PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013093508-A2 | WNT PATHWAY INHIBITORS | OSLO UNIVERSITY HOSPITAL HF (NO) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013093508-A2 | WNT PATHWAY INHIBITORS | OSLO UNIVERSITY HOSPITAL HF (NO) | 2013-06-27 | — | — | WO | disclosed |
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2010-07-01 | — | — | US | disclosed |
| US-7696231-B2 | Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs) | LABORATOIRES SERONO SA (CH) | 2010-04-13 | — | — | US | disclosed |
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. | 2005-02-24 | — | — | US | disclosed |
| EP-1439834-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003037328-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | PTPRO, PTPRE, PTPRZ1 | RAB9A 3219/4885SMN1; SMN2 4885/4885NPC1 1600/4885 |
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | PTPRO, PTPRE, PTPRZ1 | RAB9A 3161/4885SMN1; SMN2 4885/4885NPC1 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.