Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.34 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 4/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.33 |
| ▸ | MCTS1 | Q9ULC4 | 3/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28348072 | 0.92 | HSD11B1 (0.42) | HSD11B1NR1H4KDM1ANPFFR1NPFFR2 | |
| SCHEMBL28348073 | 0.82 | NPFFR1 (0.45) | HSD11B1NR1H4NPFFR1NPFFR2SLC16A3 | |
| SCHEMBL29930557 | 0.81 | NPFFR1 (0.50) | HSD11B1NR1H4NPFFR1NPFFR2SLC16A3 | |
| SCHEMBL29930039 | 0.80 | ATM (0.41) | HSD11B1NR1H4KDM1ANPFFR1NPFFR2 | |
| SCHEMBL2824379 | 0.76 | HSD11B1 (0.52) | HSD11B1NR1H4JAK2JAK1KMT2A | |
| SCHEMBL13841892 | 0.76 | HSD11B1 (0.52) | HSD11B1NR1H4JAK2JAK1KMT2A | |
| SCHEMBL2822792 | 0.74 | HSD11B1 (0.50) | HSD11B1NR1H4KDM1AHDAC8HDAC6 | |
| SCHEMBL13841889 | 0.74 | HSD11B1 (0.50) | HSD11B1NR1H4KDM1AHDAC8HDAC6 | |
| SCHEMBL26966069 | 0.69 | HSD11B1 (0.52) | HSD11B1NR1H4JAK2JAK1 | |
| SCHEMBL2819571 | 0.67 | HTR2A (0.46) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110546136-A | proline-based neuropeptide FF receptor modulators | RES TRIANGLE INST | 2019-12-06 | — | — | CN | disclosed |