Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 5/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.73 |
| ▸ | MITF | O75030 | 1/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.62 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.61 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.61 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263820 | 0.93 | NPC1 (0.83) | PTPN1NPC1RAB9AATMPSMD14 | |
| SCHEMBL8660366 | 0.93 | NPC1 (0.83) | PTPN1NPC1RAB9AATMPSMD14 | |
| SCHEMBL5697470 | 0.91 | NR1H4 (0.68) | PTPN1NPC1RAB9AATMMEN1 | |
| SCHEMBL62930 | 0.89 | PTPN1 (0.90) | PTPN1NPC1RAB9AATMPSMD14 | |
| SCHEMBL2835923 | 0.87 | PTPN1 (0.81) | PTPN1NPC1RAB9AATMPSMD14 | |
| SCHEMBL8827340 | 0.87 | MITF (0.81) | PTPN1NPC1RAB9AMITFFFAR1 | |
| SCHEMBL900903 | 0.87 | MITF (0.81) | PTPN1NPC1RAB9AMITFFFAR1 | |
| SCHEMBL28419632 | 0.87 | MITF (0.81) | PTPN1NPC1RAB9AMITFFFAR1 | |
| SCHEMBL4609805 | 0.86 | NPC1 (0.79) | PTPN1NPC1RAB9AATMPSMD14 | |
| SCHEMBL4610131 | 0.86 | NPC1 (0.79) | PTPN1NPC1RAB9AATMPSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2010-07-01 | — | — | US | disclosed |
| US-7696231-B2 | Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs) | LABORATOIRES SERONO SA (CH) | 2010-04-13 | — | — | US | disclosed |
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. | 2005-02-24 | — | — | US | disclosed |
| EP-1439834-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003037328-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-05-08 | — | — | WO | disclosed |
| US-6479548-B2 | P-(BENZOYLAMINO)STILBENE DERIVATIVES | TELIK, INC. | 2002-11-12 | — | — | US | disclosed |
| US-20020032218-A1 | Substituted stilbenes as glucose uptake enhancers | TELIK, INC. | 2002-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | PTPRO, PTPRE, PTPRZ1 | PTPN1 16/4885NPC1 1600/4885RAB9A 3219/4885 |
| US-20020032218-A1 | Substituted stilbenes as glucose uptake enhancers | SLC2A1, SLC2A8, SLC2A2 | PTPN1 1380/4885NPC1 428/4885RAB9A 3467/4885 |
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | PTPRO, PTPRE, PTPRZ1 | PTPN1 16/4885NPC1 1625/4885RAB9A 3161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.