SCHEMBL8660366

SCHEMBL8660366

COC(=O)c1ccc(C(=O)Nc2ccc(NC(=O)c3ccc(C(=O)OC)cc3)cc2)cc1

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 8/20 0.83
RAB9A P51151 8/20 0.83
ATM Q13315 1/20 0.83
PTPN1 P18031 1/20 0.77
KMT2A Q03164 6/20 0.69
MEN1 O00255 5/20 0.69
SMN1; SMN2 Q16637 5/20 0.69
TP53 P04637 3/20 0.69
ALOX15 P16050 1/20 0.69
PSMD14 O00487 1/20 0.69
CACNA1B Q00975 1/20 0.69
APBA1 Q02410 1/20 0.69
ALDH1A1 P00352 4/20 0.67
KDM4E B2RXH2 3/20 0.67
LMNA P02545 2/20 0.67
TSHR P16473 1/20 0.67
HSD17B10 Q99714 1/20 0.67
L3MBTL1 Q9Y468 1/20 0.67
MAPK1 P28482 2/20 0.66
PKM P14618 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6263820 1.00 NPC1 (0.83) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL2834528 0.93 PTPN1 (0.73) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL4609805 0.93 NPC1 (0.79) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL4610131 0.93 NPC1 (0.79) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL62930 0.93 PTPN1 (0.90) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL6243177 0.92 NPC1 (0.72) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL21242859 0.91 NPC1 (0.71) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL22640296 0.91 RAB9A (0.86) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL21242607 0.91 NPC1 (0.71) NPC1RAB9AATMPTPN1KMT2A
SCHEMBL3637607 0.91 RAB9A (1.00) NPC1RAB9AATMPTPN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130251778-A1 MEDICAL DEVICES FOR THERAPEUTIC AGENT DELIVERY WITH POLYMERIC REGIONS THAT CONTAIN COPOLYMERS HAVING BOTH SOFT SEGMENTS AND UNIFORM LENGTH HARD SEGMENTS BOSTON SCIENTIFIC SCIMED, INC. (US) 2013-09-26 US disclosed
US-8440214-B2 Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments BOSTON SCIENTIFIC SCIMED, INC. (US) 2013-05-14 US disclosed
US-8440214-B2 Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments BOSTON SCIENTIFIC SCIMED, INC. (US) 2013-05-14 US disclosed
US-20070178136-A1 Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments BOSTON SCIENTIFIC SCIMED, INC. 2007-08-02 US disclosed
US-20070178136-A1 Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments BOSTON SCIENTIFIC SCIMED, INC. 2007-08-02 US disclosed
EP-0724568-B1 AMIDO PEROXYCARBOXYLIC ACIDS FOR BLEACHING UNILEVER PLC (GB) 1998-11-04 EP disclosed
EP-0564251-B1 Amido peroxycarboxylic acids UNILEVER PLC (GB) 1995-09-06 EP disclosed
US-5397501-A Composition with surfactants for bleaching fabrics LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1995-03-14 US disclosed
US-5268003-A Or salt thereof LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1993-12-07 US disclosed
EP-0564251-A2 Amido peroxycarboxylic acids UNILEVER PLC (GB) 1993-10-06 EP disclosed
EP-0564250-A2 Structured liquid detergent compositions containing amido and imido peroxy acids UNILEVER PLC (GB) 1993-10-06 EP disclosed