SCHEMBL28345736

SCHEMBL28345736

Fc1c(F)c(-c2ccccc2)c(F)c(F)c1I

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
ALDH1A1 P00352 1/20 0.38
TYMP P19971 1/20 0.36
GRM5 P41594 1/20 0.36
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
DHODH Q02127 8/20 0.35
DHFR P00374 5/20 0.34
MAPK1 P28482 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
ACHE P22303 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24701508 0.90 MAPT (0.40) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL7711087 0.87 ALDH1A1 (0.50) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL247368 0.84 LMNA (0.48) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL14182621 0.84 LMNA (0.48) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL7704707 0.81 LMNA (0.46) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL1179753 0.81 ALDH1A1 (0.50) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL31305580 0.79 LMNA (0.43) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL17747946 0.78 LMNA (0.48) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL7713106 0.78 LMNA (0.48) LMNAMAPTHTTALDH1A1TYMP
SCHEMBL12795570 0.77 LMNA (0.42) LMNAMAPTHTTALDH1A1TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107021883-B Synthetic method and application of polysubstituted biphenyl halide liquid crystal intermediate HEBEI MAISON CHEMICAL CO., LTD. (CN) 2019-12-10 CN claimed
CN-107021883-B Synthetic method and application of polysubstituted biphenyl halide liquid crystal intermediate HEBEI MAISON CHEMICAL CO., LTD. (CN) 2019-12-10 CN disclosed