Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | FABP2 | P12104 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.36 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811461 | 0.72 | CYP1A2 (0.39) | PPARACYP2C19CYP1A2CYP3A4MEN1 | |
| SCHEMBL19320567 | 0.69 | CYP1A2 (0.45) | PPARACYP2C19CYP1A2CYP3A4MEN1 | |
| SCHEMBL25705343 | 0.68 | TSHR (0.40) | MEN1KMT2ATSHRBRD4LMNA | |
| SCHEMBL16284855 | 0.67 | POLB (0.51) | PPARACYP2C19MEN1KMT2AMAPT | |
| SCHEMBL16284849 | 0.67 | POLB (0.51) | PPARACYP2C19MEN1KMT2AMAPT | |
| SCHEMBL16284847 | 0.67 | POLB (0.51) | PPARACYP2C19MEN1KMT2AMAPT | |
| SCHEMBL27644259 | 0.67 | GABBR2 (0.46) | PPARACYP2C19CYP1A2CYP3A4MEN1 | |
| SCHEMBL9332603 | 0.66 | TSHR (0.43) | CYP2C19MEN1KMT2ACYP2C9TSHR | |
| SCHEMBL7711076 | 0.66 | POLB (0.58) | CYP2C19CYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL1742115 | 0.66 | POLB (0.58) | CYP2C19CYP3A4MEN1CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678462-A | Isoindolinone inhibitors of MDM2-P53 interaction and methods of making the same | 阿斯泰克斯治疗有限公司 | 2020-01-10 | — | — | CN | disclosed |