SCHEMBL28348024

SCHEMBL28348024

CC=CCc1ccc(-c2cccs2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.62
CYP17A1 P05093 1/20 0.51
CYP11B1 P15538 1/20 0.51
CYP11B2 P19099 1/20 0.51
PRMT6 Q96LA8 1/20 0.44
KCNH2 Q12809 1/20 0.43
LPL P06858 1/20 0.41
LIPG Q9Y5X9 1/20 0.41
HDAC2 Q92769 1/20 0.39
HDAC1 Q13547 4/20 0.38
HDAC6 Q9UBN7 2/20 0.38
HTR1D P28221 1/20 0.38
HTR1B P28222 1/20 0.38
ERN1 O75460 1/20 0.37
GSK3B P49841 1/20 0.37
CYP2E1 P05181 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2A6 P11509 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2B6 P20813 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27594388 0.83 LTA4H (0.58) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL28348015 0.82 LTA4H (0.53) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL3245398 0.80 LTA4H (0.63) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL10564184 0.79 LTA4H (0.61) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL4316723 0.78 LTA4H (0.56) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL112455 0.77 LTA4H (1.00) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL404521 0.76 LTA4H (0.68) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
Iodide SCHEMBL30800725 0.76 LTA4H (0.96) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL5828519 0.76 LTA4H (0.68) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL338810 0.74 LTA4H (0.70) LTA4HCYP17A1CYP11B1CYP11B2PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110563531-B Synthetic method of 1, 2-disubstituted olefin compound 浙江工业大学 2022-06-21 CN disclosed
CN-110563531-A Synthetic method of 1, 2-disubstituted olefin compound 浙江工业大学 2019-12-13 CN disclosed