SCHEMBL28348349

SCHEMBL28348349

COC(=O)c1cc(C(C)=O)nc(C(C)=O)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.57
ALDH1A1 P00352 1/20 0.57
CA1 P00915 4/20 0.52
CA2 P00918 4/20 0.52
CA12 O43570 3/20 0.52
CA7 P43166 3/20 0.52
CA9 Q16790 3/20 0.52
CA14 Q9ULX7 3/20 0.52
XDH P47989 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
LMNA P02545 1/20 0.50
POLB P06746 1/20 0.50
GAA P10253 1/20 0.50
NFKB1 P19838 1/20 0.50
GFER P55789 1/20 0.50
NFKB2 Q00653 1/20 0.50
RELA Q04206 1/20 0.50
FUT7 Q11130 1/20 0.50
MAPK1 P28482 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3860583 0.87 ALDH1A1 (0.49) KDM4EALDH1A1CA1CA2CA12
SCHEMBL25637857 0.85 TSHR (0.53) KDM4EALDH1A1CA1CA2CA12
SCHEMBL31369108 0.81 KDM4E (0.42) KDM4EALDH1A1CA1CA2CA12
SCHEMBL26162772 0.80 CA12 (0.48) KDM4EALDH1A1CA1CA2CA12
SCHEMBL20223143 0.80 SMN1; SMN2 (0.44) KDM4EALDH1A1TDP1LMNAGAA
SCHEMBL10383192 0.80 KDM4E (0.53) KDM4EALDH1A1CA1CA2CA12
SCHEMBL24027300 0.80 CA5A (0.50) KDM4EALDH1A1TDP1L3MBTL1LMNA
SCHEMBL31063818 0.79 CA12 (0.56) CA1CA2CA12CA7CA9
SCHEMBL12691213 0.79 NQO2 (0.50) KDM4EALDH1A1GAAMAPK1NPSR1
SCHEMBL25483408 0.79 MAPK1 (0.41) KDM4EALDH1A1LMNAGAAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110721745-B Anti-poisoning water-soluble peroxide decomposition catalyst and preparation method and application thereof 中山大学 2020-09-08 CN claimed
CN-110396200-B Preparation method of covalent macrocycle containing hepta-coordination metal catalytic center 中山大学 2020-07-03 CN claimed
CN-110721745-A Anti-poisoning water-soluble peroxide decomposition catalyst and preparation method and application thereof 中山大学 2020-01-24 CN claimed
CN-111771001-B Enhanced nucleic acid polymerization by aromatic compounds F·霍夫曼-罗氏股份公司 2024-09-06 CN disclosed
CN-110721745-B Anti-poisoning water-soluble peroxide decomposition catalyst and preparation method and application thereof 中山大学 2020-09-08 CN disclosed
CN-110396200-B Preparation method of covalent macrocycle containing hepta-coordination metal catalytic center 中山大学 2020-07-03 CN disclosed
CN-110721745-A Anti-poisoning water-soluble peroxide decomposition catalyst and preparation method and application thereof 中山大学 2020-01-24 CN disclosed