Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256531 | 0.81 | L3MBTL1 (0.49) | POLBL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL4484727 | 0.80 | L3MBTL1 (0.59) | POLBL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL6471436 | 0.78 | L3MBTL1 (0.46) | POLBL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL6471478 | 0.76 | HTT (0.45) | POLBL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL4380048 | 0.74 | MAPK14 (0.51) | POLBL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL6471390 | 0.73 | ALDH1A1 (0.51) | POLBL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL5033245 | 0.73 | POLB (0.45) | POLBL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL27458026 | 0.73 | MAPT (0.50) | MAPTLMNASMN1; SMN2HTTKDM4E | |
| SCHEMBL6472545 | 0.72 | MAOB (0.50) | POLBL3MBTL1NSD2ABL1PPARG | |
| SCHEMBL945488 | 0.71 | L3MBTL1 (0.50) | POLBL3MBTL1NSD2ABL1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043396-A1 | INDOLE AND BENZOMORPHOLINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |