Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.49 |
| ▸ | FLT4 | P35916 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30407691 | 0.76 | KDR (0.62) | KDRPDGFRAPDGFRBFLT4FLT3 | |
| SCHEMBL20547581 | 0.76 | KDR (0.62) | KDRPDGFRAPDGFRBFLT4FLT3 | |
| SCHEMBL26102003 | 0.74 | EGFR (0.39) | KDRPDGFRAPDGFRBFLT4FLT3 | |
| SCHEMBL26103100 | 0.74 | PIK3CD (0.41) | KDRPDGFRAPDGFRBFLT3 | |
| SCHEMBL14967551 | 0.73 | KDR (0.67) | KDRPDGFRAPDGFRBFLT4CSF1R | |
| SCHEMBL26100989 | 0.73 | KDR (0.39) | KDRPDGFRAPDGFRBFLT4FLT3 | |
| SCHEMBL20547350 | 0.73 | PDGFRB (0.55) | KDRPDGFRAPDGFRBFLT4FLT3 | |
| SCHEMBL30408200 | 0.73 | PDGFRB (0.55) | KDRPDGFRAPDGFRBFLT4FLT3 | |
| SCHEMBL20548339 | 0.73 | KDR (0.57) | KDRPDGFRAPDGFRBFLT4FLT3 | |
| SCHEMBL30407674 | 0.73 | KDR (0.57) | KDRPDGFRAPDGFRBFLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110546147-A | Phenoxyquinazoline compounds and their use in the treatment of cancer | ASTRAZENECA AB | 2019-12-06 | — | — | CN | claimed |
| CN-110546147-A | Phenoxyquinazoline compounds and their use in the treatment of cancer | ASTRAZENECA AB | 2019-12-06 | — | — | CN | disclosed |