Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1-Methyltryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ARG1 | P05089 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Methyltryptophan SCHEMBL14202956 | 0.96 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84CA2 | |
| Indoximod SCHEMBL29349777 | 0.96 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84CA2 | |
| 1-Methyltryptophan SCHEMBL19992 | 0.96 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84CA2 | |
| Indoximod SCHEMBL934800 | 0.96 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84CA2 | |
| (L)-1-Methyltryptophan SCHEMBL19993 | 0.96 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84CA2 | |
| Indoximod SCHEMBL23668055 | 0.94 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84CA2 | |
| Indoximod SCHEMBL18395435 | 0.94 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84CA2 | |
| Indoximod SCHEMBL30025427 | 0.94 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84CA2 | |
| 1-Methyltryptophan SCHEMBL23668056 | 0.94 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84CA2 | |
| 1-Methyltryptophan SCHEMBL20137858 | 0.94 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110585131-A | Chemotherapy drug co-loaded 1-methyltryptophan immune prodrug micelle, preparation method and application thereof | 宁夏医科大学 | 2019-12-20 | — | — | CN | claimed |
| CN-110585131-A | Chemotherapy drug co-loaded 1-methyltryptophan immune prodrug micelle, preparation method and application thereof | 宁夏医科大学 | 2019-12-20 | — | — | CN | disclosed |