Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.69 |
| ▸ | ACLY | P53396 | 7/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 3/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.39 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28355158 | 0.93 | SIRT6 (0.70) | SIRT6ACLYCPT2CPT1ACPT1B | |
| SCHEMBL23260610 | 0.90 | SIRT6 (0.84) | SIRT6ACLYFABP4FABP5GPR27 | |
| SCHEMBL28355358 | 0.90 | SIRT6 (0.83) | SIRT6ACLYFABP4FABP5GPR27 | |
| SCHEMBL23246158 | 0.90 | SIRT6 (0.83) | SIRT6ACLYFABP4FABP5GPR27 | |
| SCHEMBL28883674 | 0.90 | SIRT6 (0.83) | SIRT6ACLYFABP4FABP5GPR27 | |
| SCHEMBL23246163 | 0.90 | SIRT6 (0.83) | SIRT6ACLYFABP4FABP5GPR27 | |
| SCHEMBL23246185 | 0.83 | SIRT6 (0.56) | SIRT6ACLYFABP4FABP5GPR27 | |
| SCHEMBL28355481 | 0.83 | SIRT6 (0.56) | SIRT6FABP4FABP5GPR27 | |
| SCHEMBL29561258 | 0.82 | SIRT6 (1.00) | SIRT6ACLYFABP4FABP5GPR27 | |
| SCHEMBL23261498 | 0.81 | SIRT6 (0.84) | SIRT6ACLYCPT2CPT1ACPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642757-A | Compound with activation SIRT6 acetylation activity, SIRT6 agonist and application thereof | 上海交通大学医学院 | 2020-01-03 | — | — | CN | disclosed |