Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzodiazepine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 4/20 | 0.31 |
| ▸ | JAK1 | P23458 | 4/20 | 0.31 |
| ▸ | TYK2 | P29597 | 4/20 | 0.31 |
| ▸ | JAK3 | P52333 | 4/20 | 0.31 |
| ▸ | ACR | P10323 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzodiazepine SCHEMBL14740757 | 0.88 | MAPT (0.35) | — | |
| Benzodiazepine SCHEMBL27880113 | 0.84 | P2RX4 (0.34) | P2RX4 | |
| Benzodiazepine SCHEMBL1574261 | 0.83 | MAPT (0.36) | P2RX4 | |
| Benzodiazepine SCHEMBL4553535 | 0.83 | ALPI (0.36) | — | |
| Benzodiazepine SCHEMBL29151800 | 0.82 | MAPT (0.35) | P2RX4 | |
| Benzodiazepine SCHEMBL22578992 | 0.81 | MAPT (0.33) | P2RX4 | |
| Benzodiazepine SCHEMBL29040975 | 0.81 | GAA (0.32) | P2RX4 | |
| Benzodiazepine SCHEMBL4971764 | 0.80 | MAPT (0.36) | P2RX4 | |
| Benzodiazepine SCHEMBL633678 | 0.80 | GAA (0.36) | — | |
| Benzodiazepine SCHEMBL11469198 | 0.80 | MAPT (0.36) | P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111511364-A | Targeted therapeutic agents | 马德里加尔制药公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-110799194-A | Combination therapy comprising targeted therapeutic agents | 马德里加尔制药公司 | 2020-02-14 | — | — | CN | disclosed |