Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CRHBP | P24387 | 2/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7563670 | 0.98 | MAPT (0.56) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL8964829 | 0.87 | TDP1 (0.62) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL8973475 | 0.83 | TDP1 (0.62) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL8163363 | 0.82 | NPBWR1 (0.44) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL4856346 | 0.82 | HTT (0.53) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL8156901 | 0.82 | MAPT (0.46) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL1148687 | 0.82 | ALDH1A1 (0.57) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL7568613 | 0.82 | CYP19A1 (0.57) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL7568708 | 0.81 | CA12 (0.54) | MAPTALDH1A1HTTTDP1KMT2A | |
| SCHEMBL7602158 | 0.81 | CA12 (0.54) | MAPTALDH1A1HTTTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170827-B1 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | JANSSEN PHARMACEUTICA NV (BE) | 2013-08-14 | — | — | EP | disclosed |
| US-8338422-B2 | Indolin-2-ones and aza-indolin-2-ones | JANSSEN PHARMACEUTICA NV (BE) | 2012-12-25 | — | — | US | disclosed |
| US-20100190786-A1 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-29 | — | — | US | disclosed |
| EP-2170827-A2 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | Janssen Pharmaceutica, N.V. (BE) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008155421-A2 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190786-A1 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | IDO2, IDO1, MKI67 | MAPT 4356/4885ALDH1A1 1617/4885HTT 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.