Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.85 |
| ▸ | JAK2 | O60674 | 11/20 | 0.85 |
| ▸ | JAK1 | P23458 | 3/20 | 0.85 |
| ▸ | JAK3 | P52333 | 3/20 | 0.85 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362658 | 0.92 | TYK2 (1.00) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29552223 | 0.87 | TYK2 (0.86) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29551994 | 0.86 | TYK2 (0.69) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29552183 | 0.81 | TYK2 (0.85) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29551800 | 0.81 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL28362542 | 0.81 | TYK2 (0.76) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29552999 | 0.81 | TYK2 (0.57) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL28362686 | 0.80 | TYK2 (0.66) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922578 | 0.80 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL28358907 | 0.79 | TYK2 (0.77) | TYK2JAK2JAK1JAK3DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |