Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.57 |
| ▸ | JAK2 | O60674 | 4/20 | 0.57 |
| ▸ | JAK1 | P23458 | 4/20 | 0.57 |
| ▸ | JAK3 | P52333 | 3/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 2/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359418 | 0.89 | TYK2 (0.54) | TYK2JAK2JAK1JAK3AKR1C3 | |
| SCHEMBL29552398 | 0.85 | JAK2 (0.54) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL28359245 | 0.81 | TYK2 (0.85) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29552260 | 0.79 | MAPT (0.52) | DGAT1MAPT | |
| SCHEMBL29922674 | 0.74 | INSR (0.45) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL28358963 | 0.74 | INSR (0.45) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL28359240 | 0.74 | JAK2 (0.52) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL29922581 | 0.74 | JAK2 (0.52) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL21384014 | 0.73 | TYK2 (0.63) | TYK2JAK2JAK1JAK3CCND3 | |
| SCHEMBL29551893 | 0.73 | MEN1 (0.40) | TYK2JAK2JAK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |