Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.85 |
| ▸ | JAK2 | O60674 | 5/20 | 0.85 |
| ▸ | JAK1 | P23458 | 5/20 | 0.85 |
| ▸ | JAK3 | P52333 | 5/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359087 | 0.92 | TYK2 (1.00) | TYK2JAK2JAK1JAK3AURKA | |
| SCHEMBL28359040 | 0.90 | TYK2 (0.81) | TYK2JAK2JAK1JAK3KDM4E | |
| SCHEMBL29922746 | 0.90 | TYK2 (0.81) | TYK2JAK2JAK1JAK3KDM4E | |
| SCHEMBL29551892 | 0.88 | TYK2 (0.67) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29552228 | 0.82 | TYK2 (0.61) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29551800 | 0.81 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL28359245 | 0.81 | TYK2 (0.85) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL28884127 | 0.80 | TYK2 (0.79) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29552398 | 0.80 | JAK2 (0.54) | TYK2JAK2JAK1JAK3KDM4E | |
| SCHEMBL29552110 | 0.80 | JAK2 (0.55) | TYK2JAK2JAK1JAK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |