Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 7/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922511 | 1.00 | DHODH (0.44) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29552219 | 0.92 | DHODH (0.48) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29552324 | 0.91 | JAK2 (0.48) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL28359105 | 0.91 | JAK2 (0.48) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29552248 | 0.84 | ABCB1 (0.41) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL28358863 | 0.84 | ABCB1 (0.41) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL29922466 | 0.84 | ABCB1 (0.41) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL29922686 | 0.83 | JAK2 (0.42) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29922784 | 0.82 | DHODH (0.45) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL28362738 | 0.82 | DHODH (0.45) | DHODHTYK2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |