Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 8/20 | 0.40 |
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362738 | 1.00 | DHODH (0.45) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29552340 | 1.00 | DHODH (0.45) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29552123 | 0.90 | DHODH (0.52) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29551879 | 0.89 | JAK2 (0.51) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL28358910 | 0.89 | JAK2 (0.51) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29922647 | 0.85 | JAK2 (0.44) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL28358976 | 0.85 | JAK2 (0.44) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL28359299 | 0.82 | DHODH (0.44) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29922511 | 0.82 | DHODH (0.44) | DHODHTYK2JAK2JAK1JAK3 | |
| SCHEMBL29552428 | 0.80 | SYK (0.43) | DHODHL3MBTL1MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |