Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.44 |
| ▸ | JAK1 | P23458 | 9/20 | 0.44 |
| ▸ | JAK3 | P52333 | 7/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552317 | 0.93 | TYK2 (0.36) | JAK2JAK1JAK3TYK2ALOX5AP | |
| SCHEMBL29922698 | 0.92 | TYK2 (0.36) | JAK2JAK1JAK3TYK2ALOX5AP | |
| SCHEMBL28359021 | 0.92 | TYK2 (0.36) | JAK2JAK1JAK3TYK2ALOX5AP | |
| SCHEMBL29552173 | 0.88 | TYK2 (0.48) | JAK2JAK1JAK3TYK2KDM1A | |
| SCHEMBL28362626 | 0.87 | JAK1 (0.49) | JAK2JAK1JAK3TYK2RORC | |
| SCHEMBL29553135 | 0.84 | JAK2 (0.39) | JAK2JAK1JAK3TYK2RORC | |
| SCHEMBL28359066 | 0.83 | TYK2 (0.49) | JAK2JAK1JAK3TYK2KDM1A | |
| SCHEMBL28359221 | 0.78 | JAK3 (0.52) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL29552283 | 0.78 | JAK2 (0.49) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL29922752 | 0.78 | JAK2 (0.49) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |