Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359021 | 1.00 | TYK2 (0.36) | TYK2JAK2JAK1JAK3KDM1A | |
| SCHEMBL29552317 | 0.93 | TYK2 (0.36) | TYK2JAK2JAK1JAK3KDM1A | |
| SCHEMBL28359374 | 0.92 | JAK2 (0.44) | TYK2JAK2JAK1JAK3KDM1A | |
| SCHEMBL29552173 | 0.80 | TYK2 (0.48) | TYK2JAK2JAK1JAK3KDM1A | |
| SCHEMBL28362626 | 0.79 | JAK1 (0.49) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL29922895 | 0.79 | JAK3 (0.47) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL28359056 | 0.79 | JAK3 (0.47) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL28362552 | 0.78 | JAK2 (0.40) | TYK2JAK2JAK1JAK3IRAK4 | |
| SCHEMBL29552783 | 0.78 | JAK2 (0.40) | TYK2JAK2JAK1JAK3IRAK4 | |
| SCHEMBL28359233 | 0.74 | TYK2 (0.40) | TYK2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |