Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.49 |
| ▸ | JAK2 | O60674 | 9/20 | 0.49 |
| ▸ | JAK1 | P23458 | 9/20 | 0.49 |
| ▸ | JAK3 | P52333 | 9/20 | 0.49 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362626 | 0.89 | JAK1 (0.49) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL29552173 | 0.88 | TYK2 (0.48) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL29553135 | 0.86 | JAK2 (0.39) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL28359374 | 0.83 | JAK2 (0.44) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL28359221 | 0.80 | JAK3 (0.52) | TYK2JAK2JAK1JAK3PIM1 | |
| SCHEMBL29551832 | 0.80 | TYK2 (0.37) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL29551888 | 0.76 | JAK2 (0.59) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28362532 | 0.75 | JAK2 (0.51) | TYK2JAK2JAK1JAK3RORC | |
| SCHEMBL29552249 | 0.73 | TYK2 (0.58) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28359236 | 0.73 | TYK2 (0.58) | TYK2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |