Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28361041 | 0.94 | CSNK1D (0.36) | CSNK1DCSNK1EGRIN2BGRM4NPC1 | |
| SCHEMBL28357358 | 0.92 | GRM4 (0.42) | CSNK1DCSNK1EGRIN2BGRM4LMNA | |
| SCHEMBL28361088 | 0.91 | HTR6 (0.33) | HTR6TP53GRIN2BSMN1; SMN2GRM4 | |
| SCHEMBL17925514 | 0.89 | SMN1; SMN2 (0.35) | HTR6TP53GRIN2BSMN1; SMN2GRM4 | |
| SCHEMBL28361004 | 0.89 | CSNK1D (0.35) | CSNK1DCSNK1EGRM4 | |
| SCHEMBL28357469 | 0.87 | CSNK1D (0.36) | CSNK1DCSNK1ETP53GRIN2BSMN1; SMN2 | |
| SCHEMBL28361300 | 0.87 | CSNK1D (0.35) | CSNK1DCSNK1E | |
| SCHEMBL28361100 | 0.87 | CSNK1D (0.35) | CSNK1DCSNK1EGRM4 | |
| SCHEMBL28361097 | 0.86 | CSNK1D (0.35) | CSNK1DCSNK1EHTR6GRIN2BSMN1; SMN2 | |
| SCHEMBL28357366 | 0.85 | CSNK1D (0.35) | CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110804061-B | Pyrazole and pyrazine formamide compound containing cyclopropyl segment and application thereof | 中国医学科学院医药生物技术研究所 | 2021-01-05 | — | — | CN | claimed |
| CN-110804061-A | Pyrazole and pyrazine formamide compound containing cyclopropyl segment and application thereof | 中国医学科学院医药生物技术研究所 | 2020-02-18 | — | — | CN | claimed |
| CN-110804061-B | Pyrazole and pyrazine formamide compound containing cyclopropyl segment and application thereof | 中国医学科学院医药生物技术研究所 | 2021-01-05 | — | — | CN | disclosed |
| CN-110804061-A | Pyrazole and pyrazine formamide compound containing cyclopropyl segment and application thereof | 中国医学科学院医药生物技术研究所 | 2020-02-18 | — | — | CN | disclosed |