SCHEMBL28362124

SCHEMBL28362124

c1ccc(Oc2ccccc2C2CCCNC2)cc1

nearest known ligand 0.68

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 8/20 0.68
SLC6A4 P31645 8/20 0.68
HTR1A P08908 7/20 0.68
SLC6A3 Q01959 7/20 0.68
KDM1A O60341 2/20 0.46
HTR2A P28223 3/20 0.45
CYP2D6 P10635 1/20 0.44
KCNH2 Q12809 1/20 0.44
HTR2C P28335 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21359054 0.81 HTR2C (0.66) HTR1AHTR2AHTR2C
SCHEMBL30952439 0.81 HTR2C (0.66) HTR1AHTR2AHTR2C
SCHEMBL27995550 0.81 HTR2C (0.66) HTR1AHTR2AHTR2C
SCHEMBL2145214 0.81 HTR2C (0.66) HTR1AHTR2AHTR2C
SCHEMBL30952441 0.81 HTR2C (0.66) HTR1AHTR2AHTR2C
SCHEMBL4699769 0.81 SLC6A2 (1.00) SLC6A2SLC6A4HTR1ASLC6A3KDM1A
SCHEMBL7598684 0.80 HTR1A (0.70) SLC6A2SLC6A4HTR1ASLC6A3KDM1A
Hydrochloric Acid SCHEMBL567684 0.80 HTR2C (0.67) HTR1AHTR2AHTR2C
SCHEMBL22944333 0.80 BTK (0.50) KDM1AHTR2AKCNH2HTR2C
SCHEMBL16455100 0.78 HTR2A (0.47) HTR1AHTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110662742-A Novel crystalline forms of 1- (4- { [ 6-amino-5- (4-phenoxy-phenyl) -pyrimidin-4-ylamino ] -methyl } -piperidin-1-yl) -propenone 默克专利有限公司 2020-01-07 CN disclosed