Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 13/20 | 0.66 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 5/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | RECQL | P46063 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | APEX1 | P27695 | 2/20 | 0.66 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.66 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362223 | 0.83 | EP300 (0.65) | EP300CREBBPKDM4EALDH1A1POLB | |
| SCHEMBL29711734 | 0.80 | EP300 (1.00) | EP300CREBBPPOLBMEN1KMT2A | |
| SCHEMBL12092858 | 0.80 | EP300 (1.00) | EP300CREBBPPOLBMEN1KMT2A | |
| SCHEMBL14991291 | 0.80 | EP300 (1.00) | EP300CREBBPPOLBMEN1KMT2A | |
| SCHEMBL29441235 | 0.80 | EP300 (1.00) | EP300CREBBPPOLBMEN1KMT2A | |
| SCHEMBL14991292 | 0.80 | EP300 (1.00) | EP300CREBBPPOLBMEN1KMT2A | |
| SCHEMBL6397407 | 0.79 | TDP1 (1.00) | KDM4EALDH1A1POLBTDP1MAPT | |
| SCHEMBL6397410 | 0.79 | TDP1 (1.00) | KDM4EALDH1A1POLBTDP1MAPT | |
| SCHEMBL28883613 | 0.79 | EP300 (1.00) | EP300CREBBPMEN1KMT2ARAB9A | |
| SCHEMBL28848284 | 0.78 | EP300 (0.71) | EP300CREBBPALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862383-A | Histone acetyltransferase P300 small-molecule inhibitor, medicinal composition thereof and application thereof | 复旦大学 | 2020-03-06 | — | — | CN | disclosed |