Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.57 |
| ▸ | TYK2 | P29597 | 11/20 | 0.57 |
| ▸ | JAK1 | P23458 | 10/20 | 0.57 |
| ▸ | JAK3 | P52333 | 10/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29551888 | 0.87 | JAK2 (0.59) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28362639 | 0.87 | JAK2 (0.44) | JAK2TYK2JAK1JAK3AKR1C3 | |
| SCHEMBL29552249 | 0.85 | TYK2 (0.58) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28359236 | 0.85 | TYK2 (0.58) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28359205 | 0.83 | JAK2 (0.56) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29551923 | 0.82 | TYK2 (0.55) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28883611 | 0.82 | JAK2 (0.59) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL28362706 | 0.82 | JAK2 (0.55) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL28359254 | 0.82 | JAK2 (0.55) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28884120 | 0.82 | TYK2 (0.55) | JAK2TYK2JAK1JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |