Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.58 |
| ▸ | JAK2 | O60674 | 12/20 | 0.58 |
| ▸ | JAK1 | P23458 | 10/20 | 0.58 |
| ▸ | JAK3 | P52333 | 10/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552249 | 1.00 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL28359167 | 0.92 | JAK2 (0.69) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29551995 | 0.92 | JAK2 (0.69) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29551888 | 0.90 | JAK2 (0.59) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29551925 | 0.90 | JAK1 (0.52) | TYK2JAK2JAK1JAK3AURKA | |
| SCHEMBL28362555 | 0.90 | JAK1 (0.52) | TYK2JAK2JAK1JAK3AURKA | |
| SCHEMBL28362706 | 0.88 | JAK2 (0.55) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29551923 | 0.85 | TYK2 (0.55) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL28884120 | 0.85 | TYK2 (0.55) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL28363100 | 0.85 | JAK2 (0.57) | TYK2JAK2JAK1JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |