SCHEMBL2836355

SCHEMBL2836355

CO/C(=C/C(=O)O)COc1cc(N=C=O)c(F)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
TDP1 Q9NUW8 3/20 0.33
TSHR P16473 2/20 0.33
ANO1 Q5XXA6 1/20 0.31
PTGDR2 Q9Y5Y4 3/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PPOX P50336 1/20 0.31
CYP2C19 P33261 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
MAPK1 P28482 1/20 0.30
NPC1 O15118 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2836363 1.00 LMNA (0.39) LMNATDP1TSHRANO1PTGDR2
SCHEMBL2836358 1.00 LMNA (0.39) LMNATDP1TSHRANO1PTGDR2
SCHEMBL1573654 0.91 LMNA (0.39) LMNATDP1TSHRANO1PPOX
SCHEMBL1573656 0.91 LMNA (0.39) LMNATDP1TSHRANO1PPOX
SCHEMBL9530045 0.83 LMNA (0.57) LMNATDP1TSHRPTGDR2PPOX
SCHEMBL2837390 0.80 LMNA (0.43) LMNATDP1TSHRPPOXCYP2C19
SCHEMBL2837388 0.80 LMNA (0.43) LMNATDP1TSHRPPOXCYP2C19
SCHEMBL2837393 0.80 LMNA (0.43) LMNATDP1TSHRPPOXCYP2C19
SCHEMBL1573657 0.80 LMNA (0.39) LMNATDP1TSHRPTGDR2MEN1
SCHEMBL1573655 0.77 SCN9A (0.34) TSHRPTGDR2PPOXCYP2C19KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7754880-B2 Uracils having a herbicidal activity ISAGRO RICERCA S.R.L. (IT) 2010-07-13 US disclosed
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US disclosed
EP-1585737-A2 URACILS HAVING A HERBICIDAL ACTIVITY Isagro Ricerca S.r.l. (IT) 2005-10-19 EP disclosed
WO-2004056785-A2 URACILS HAVING A HERBICIDAL ACTIVITY ISAGRO RICERCA S.R.L. (IT) 2004-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060025591-A1 New uracils having a herbicidal activity UNG, DDT, UMPS LMNA 4657/4885TDP1 45/4885TSHR 2602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.