Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | BID | P55957 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6139588 | 0.93 | PDCD1 (0.47) | FOLH1PDCD1CD274PPARAKMT2A | |
| Formamide SCHEMBL12497386 | 0.87 | FOLH1 (0.41) | FOLH1PDCD1CD274PPARAKMT2A | |
| Bicarbonate SCHEMBL1835067 | 0.86 | PPARA (0.56) | FOLH1PDCD1CD274PPARAKMT2A | |
| SCHEMBL25171586 | 0.83 | FOLH1 (0.71) | FOLH1PDCD1CD274PPARAKMT2A | |
| Bicarbonate SCHEMBL17473045 | 0.83 | FOLH1 (0.46) | FOLH1PDCD1CD274PPARAKMT2A | |
| Bicarbonate SCHEMBL1836587 | 0.83 | PPARA (0.50) | FOLH1PDCD1CD274PPARAKMT2A | |
| SCHEMBL29137601 | 0.82 | ALDH1A1 (0.45) | FOLH1PDCD1CD274LTB4RLTB4R2 | |
| Bicarbonate SCHEMBL28365018 | 0.81 | FOLH1 (0.50) | FOLH1PDCD1CD274PPARAKMT2A | |
| SCHEMBL1840930 | 0.80 | LTB4R (0.46) | FOLH1PPARAPTGER1PTGER4PTGER3 | |
| SCHEMBL8674511 | 0.80 | ELANE (0.38) | PDCD1CD274PPARALTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118354903-A | Skin material | 日产自动车株式会社 | 2024-07-16 | — | — | CN | disclosed |
| CN-117480225-A | Coating agent and spring | 日本发条株式会社 | 2024-01-30 | — | — | CN | disclosed |
| CN-106515000-B | Method for producing three-dimensional shaped object and support material for three-dimensional shaping | 富士施乐株式会社 | 2021-05-07 | — | — | CN | disclosed |
| CN-106336483-B | Three-dimensional modeling material, support material for three-dimensional modeling, and composition set for three-dimensional modeling | 富士施乐株式会社 | 2021-02-02 | — | — | CN | disclosed |
| CN-105820552-B | Support material for three-dimensional molding, composition set for three-dimensional molding, three-dimensional molding apparatus, and method for producing three-dimensional molded body | 富士施乐株式会社 | 2020-02-11 | — | — | CN | disclosed |