Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 4/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15307002 | 0.79 | KMT2A (0.46) | PLATKMT2ASMN1; SMN2L3MBTL1TSHR | |
| SCHEMBL20694708 | 0.79 | PLAT (0.43) | PLATHCAR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17820828 | 0.78 | PLAT (0.36) | PLATCRBNHCAR1MEN1KMT2A | |
| SCHEMBL21313060 | 0.73 | PLAT (0.35) | PLATCRBNHCAR1MEN1KMT2A | |
| SCHEMBL406392 | 0.68 | PLAT (0.46) | PLATMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL14881615 | 0.67 | PLAT (0.53) | PLATSMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL16764938 | 0.66 | MIF (0.48) | MEN1KMT2ASMN1; SMN2TSHRMAPT | |
| SCHEMBL21313032 | 0.66 | ALDH1A1 (0.34) | SMN1; SMN2MAPTMAPK1ALDH1A1 | |
| SCHEMBL30230649 | 0.66 | PDGFRA (0.42) | SMN1; SMN2POLBTSHRMAPTKDM4E | |
| SCHEMBL15307034 | 0.66 | HTR6 (0.40) | MEN1KMT2ASMN1; SMN2POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116829562-A | Macrocyclic compound, pharmaceutical composition and application thereof | 深圳国顺康医药科技有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-115884776-A | Heterocyclic macrocyclic compounds and their medical use | 中国医药研究开发中心有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-113735881-A | Macrocyclic compounds containing aminopyrazolopyrimidines, pharmaceutical compositions and uses thereof | 正大天晴药业集团股份有限公司 | 2021-12-03 | — | — | CN | disclosed |
| CN-110945000-B | Macrocyclic compounds containing aminopyrazolopyrimidines, pharmaceutical compositions and uses thereof | 正大天晴药业集团股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-109890820-B | Aminopyrazolopyrimidine compounds as neurotrophin tyrosine kinase receptor inhibitors | 正大天晴药业集团股份有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-108003161-B | Neurotrophic factor tyrosine kinase receptor inhibitors | 正大天晴药业集团股份有限公司 | 2020-10-09 | — | — | CN | disclosed |
| CN-110945000-A | Macrocyclic compounds containing aminopyrazolopyrimidines, pharmaceutical compositions and uses thereof | 正大天晴药业集团股份有限公司 | 2020-03-31 | — | — | CN | disclosed |