Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsU
The experimentally established mechanism targets of Tobramycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.89 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.89 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | GJA1 | P17302 | 1/20 | 0.70 |
| ▸ | GJB2 | P29033 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tobramycin SCHEMBL2637031 | 1.00 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL1561126 | 1.00 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL8573253 | 1.00 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL9712239 | 1.00 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL12930900 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL3658310 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL22364334 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL20953776 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL15263385 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL19678587 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7381 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| CN-120078752-A | Particles for large-dose water-soluble medicine inhalation powder aerosol and preparation method thereof | 沈阳药科大学 | 2025-06-03 | — | — | CN | claimed |
| WO-2025111413-A1 | TREATMENT FOR SKIN DISORDERS | Mycotechnology, Inc. (US) | 2025-05-30 | — | — | WO | claimed |
| EP-4552693-A2 | COLLAGEN PEPTIDE-BASED MEDICAMENT COMPOSITIONS AND DEVICES AND METHODS OF PRODUCTION AND USE THEREOF | Sustain Holdings, LLC (US) | 2025-05-14 | — | — | EP | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-111526873-B | For modulating microbial colonization substituted diphenylacetylenes of (2) | 生物曼迪克斯有限责任公司 | 2025-03-04 | — | — | CN | claimed |
| US-20250025629-A1 | IRRIGATION SYSTEM AND METHODS OF USE | OSTEAL THERAPEUTICS, INC. | 2025-01-23 | — | — | US | claimed |
| CN-116350839-B | Preparation method of chronic wound long-term drug release dressing | 西安理工大学 | 2024-11-22 | — | — | CN | claimed |
| CN-118657982-A | Medical image big data intelligent cloud monitoring method based on deep learning | 安徽影联云享医疗科技有限公司 | 2024-09-17 | — | — | CN | claimed |
| CN-116135237-B | Preparation method of constant-speed drug release aerogel composite bone cement | 西安理工大学 | 2024-09-03 | — | — | CN | claimed |
| WO-1995002703-A1 | LYOPHILIZED LIGAND-RECEPTOR COMPLEXES FOR ASSAYS AND SENSORS | U.S. DRUG TESTING, INC. (US) | 1995-01-26 | — | — | WO | claimed |
| US-5353391-A | Computer controlled display system | APPLE COMPUTER, INC. (US) | 1994-10-04 | — | — | US | claimed |
| WO-1993023015-A1 | LIPOSOMAL AMINOGLYCOSIDE COMPOSITIONS AND PROCESS FOR THEIR PREPARATION | INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL/DEPARTAMENTO DE TECNOLOGIA DE INDÚSTRIAS QUÍMICAS (PT) | 1993-11-25 | — | — | WO | claimed |
| EP-0372070-A4 | METHOD FOR MAKING SOLVENT DILUTION MICROCARRIERS | — | 1992-01-15 | — | — | EP | claimed |
| US-5061729-A | Ear drops | BIOGAL GYOGYSZERGYAR (HU) | 1991-10-29 | — | — | US | claimed |
| EP-0207624-B1 | METHOD FOR PREPARING INFECTION-RESISTANT MATERIALS | The Trustees of Columbia University in the City of New York (US) | 1991-03-06 | — | — | EP | claimed |
| EP-0372070-A1 | METHOD FOR MAKING SOLVENT DILUTION MICROCARRIERS. | FOUNTAIN MICHAEL W | 1990-06-13 | — | — | EP | claimed |
| WO-1989011850-A1 | METHOD FOR MAKING SOLVENT DILUTION MICROCARRIERS | FOUNTAIN MICHAEL W (US) | 1989-12-14 | — | — | WO | claimed |
| US-4865846-A | Drug delivery system | KAUFMAN HERBERT E (US) | 1989-09-12 | — | — | US | claimed |
| WO-1989003041-A2 | TRIDENTATE CONJUGATE AND METHOD OF USE THEREOF | BECKMAN INSTRUMENTS, INC. (US) | 1989-04-06 | — | — | WO | claimed |