Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsU
The experimentally established mechanism targets of Tobramycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.89 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.89 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | GJA1 | P17302 | 1/20 | 0.70 |
| ▸ | GJB2 | P29033 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tobramycin SCHEMBL2637031 | 1.00 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL1561126 | 1.00 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL8573253 | 1.00 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL2837 | 1.00 | GAA (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL12930900 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL3658310 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL22364334 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL20953776 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL15263385 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT | |
| Tobramycin SCHEMBL19678587 | 0.94 | ALOX15 (1.00) | GAAALOX15HPSECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992018101-A1 | VAGINAL DRUG DELIVERY DEVICE | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | claimed |
| EP-2707026-A1 | PRODUCTION OF DENSE BODIES (DB) FROM HCMV-INFECTED CELLS | AiCuris GmbH & Co. KG (DE) | 2014-03-19 | — | — | EP | disclosed |
| WO-2012152644-A1 | PRODUCTION OF DENSE BODIES (DB) FROM HCMV-INFECTED CELLS | AICURIS GMBH & CO. KG (DE) | 2012-11-15 | — | — | WO | disclosed |
| EP-0432168-A4 | GENETICALLY ENGINEERED COCCIDIOSIS VACCINE | — | 1991-11-13 | — | — | EP | disclosed |
| EP-0432168-A1 | GENETICALLY ENGINEERED COCCIDIOSIS VACCINE. | GENEX CORP (US) | 1991-06-19 | — | — | EP | disclosed |
| WO-1990000403-A1 | GENETICALLY ENGINEERED COCCIDIOSIS VACCINE | GENEX CORPORATION (US) | 1990-01-25 | — | — | WO | disclosed |
| EP-0083999-A1 | Method of reducing or suppressing undesirable activities of biological pharmaceutical and biomedical products and materials | Shanbrom, Edward (US) | 1983-07-20 | — | — | EP | disclosed |