Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.76 |
| ▸ | BLK | P51451 | 4/20 | 0.68 |
| ▸ | ITK | Q08881 | 3/20 | 0.68 |
| ▸ | FGR | P09769 | 2/20 | 0.68 |
| ▸ | FLT3 | P36888 | 2/20 | 0.68 |
| ▸ | CSK | P41240 | 2/20 | 0.68 |
| ▸ | JAK3 | P52333 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.65 |
| ▸ | TEC | P42680 | 3/20 | 0.65 |
| ▸ | BMX | P51813 | 3/20 | 0.65 |
| ▸ | TXK | P42681 | 2/20 | 0.65 |
| ▸ | LYN | P07948 | 2/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.65 |
| ▸ | LATS1 | O95835 | 1/20 | 0.65 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28370674 | 1.00 | BTK (0.76) | BTKBLKITKFGRFLT3 | |
| SCHEMBL19635796 | 0.90 | BTK (0.77) | BTKBLKITKFGRFLT3 | |
| SCHEMBL19635809 | 0.88 | BTK (0.75) | BTKBLKITKJAK3EGFR | |
| SCHEMBL19636022 | 0.88 | BTK (0.75) | BTKBLKITKJAK3EGFR | |
| SCHEMBL16931733 | 0.87 | BTK (0.85) | BTKBLKITKFGRFLT3 | |
| SCHEMBL18095743 | 0.87 | BTK (0.85) | BTKBLKITKFGRFLT3 | |
| SCHEMBL21330632 | 0.86 | BTK (1.00) | BTKBLKITKFGRFLT3 | |
| SCHEMBL19635789 | 0.85 | BTK (0.68) | BTKBLKITKFGRFLT3 | |
| SCHEMBL19636020 | 0.85 | BTK (0.68) | BTKBLKITKFGRFLT3 | |
| SCHEMBL15515676 | 0.83 | BTK (0.74) | BTKBLKITKFGRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111153906-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111153906-A | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-107383013-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-03-31 | — | — | CN | disclosed |