Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921965 | 0.82 | IGF1R (0.44) | GSK3B | |
| SCHEMBL15940791 | 0.79 | NPC1 (0.39) | MAPK14 | |
| SCHEMBL4304915 | 0.79 | NR3C2 (0.41) | — | |
| SCHEMBL14273251 | 0.78 | BRAF (0.61) | MAPK14ACVRL1GSK3BGSK3APIK3C3 | |
| SCHEMBL7106525 | 0.78 | IGF1R (0.33) | MAPK14TYK2MAPK13 | |
| SCHEMBL30953345 | 0.76 | AAK1 (0.36) | MAPK14 | |
| SCHEMBL20387979 | 0.76 | HPGD (0.56) | TYK2ABL1 | |
| SCHEMBL24942338 | 0.75 | ACVRL1 (0.57) | ACVRL1GSK3BGSK3APIK3C3TYK2 | |
| SCHEMBL15350073 | 0.75 | TYK2 (0.62) | ACVRL1GSK3BPIK3C3TYK2ABL1 | |
| SCHEMBL30953276 | 0.75 | AAK1 (0.44) | MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108640872-B | GSK-3 inhibitor and preparation method and application thereof | 山东大学 | 2020-04-07 | — | — | CN | disclosed |