Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 7/20 | 0.57 |
| ▸ | MET | P08581 | 4/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5824349 | 0.81 | PDGFRA (0.65) | FLT3AURKBPDGFRAKDRMET | |
| SCHEMBL23880322 | 0.81 | PDGFRA (0.60) | FLT3AURKBPDGFRAKDRMET | |
| SCHEMBL2172904 | 0.80 | PDGFRA (0.64) | FLT3AURKBPDGFRAKDRMET | |
| SCHEMBL7485158 | 0.78 | FGFR2 (0.71) | FLT3AURKBPDGFRAKDRMET | |
| SCHEMBL14808762 | 0.78 | AURKB (0.67) | FLT3AURKBPDGFRAKDRMET | |
| SCHEMBL7486400 | 0.76 | FGFR2 (0.84) | PDGFRAKDREGFRPDGFRBFGFR2 | |
| SCHEMBL2176217 | 0.76 | PDGFRB (0.67) | FLT3AURKBPDGFRAKDRMET | |
| SCHEMBL30918289 | 0.75 | AXL (0.90) | FLT3AURKBPDGFRAKDRMET | |
| SCHEMBL15872120 | 0.75 | AXL (0.90) | FLT3AURKBPDGFRAKDRMET | |
| SCHEMBL1877070 | 0.75 | PDGFRA (0.84) | PDGFRAKDRMETKITAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111440119-B | Preparation method of cabozantinib intermediate | 郑州大学第一附属医院 | 2021-08-24 | — | — | CN | disclosed |
| CN-111440119-A | Preparation method of cabozantinib intermediate | 郑州大学第一附属医院 | 2020-07-24 | — | — | CN | disclosed |
| CN-110143917-B | Preparation method of cabozantinib metabolite | 郑州大学第一附属医院 | 2020-03-31 | — | — | CN | disclosed |