Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896364 | 0.90 | PLAU (0.45) | PLAUHRH3MAPK14MAPK13MAPK12 | |
| SCHEMBL29505200 | 0.90 | PLAU (0.45) | PLAUHRH3MAPK14MAPK13MAPK12 | |
| SCHEMBL16896444 | 0.87 | HRH3 (0.45) | PLAUHRH3MAPK14MAPK13MAPK12 | |
| SCHEMBL28375412 | 0.85 | HRH3 (0.44) | HRH3 | |
| SCHEMBL30461103 | 0.84 | MAPK14 (0.42) | PLAUHRH3MAPK14MAPK13MAPK12 | |
| SCHEMBL28378947 | 0.84 | MAPK14 (0.42) | PLAUHRH3MAPK14MAPK13MAPK12 | |
| SCHEMBL25908403 | 0.82 | HRH3 (0.46) | PLAUHRH3MAPK14MAPK13MAPK12 | |
| SCHEMBL30429435 | 0.76 | RAB9A (0.54) | BRAFLRRK2RAF1 | |
| SCHEMBL16896607 | 0.75 | HRH3 (0.47) | HRH3 | |
| SCHEMBL29505292 | 0.75 | HRH3 (0.47) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362966-B | Bicyclic heterocyclic derivatives as IRAK4 inhibitors | 奥列基因发现技术有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-111362966-A | Bicyclic heterocyclic derivatives as IRAK4 inhibitors | 奥列基因发现技术有限公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-106456619-B | Bicyclic heterocyclic derivatives as IRAK4 inhibitors | 奥列基因发现技术有限公司 | 2020-03-27 | — | — | CN | disclosed |