Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.53 |
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.53 |
| ▸ | KDM5A | P29375 | 6/20 | 0.53 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.53 |
| ▸ | KDM5C | P41229 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.45 |
| ▸ | KLK1 | P06870 | 3/20 | 0.45 |
| ▸ | KDM4A | O75164 | 3/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28375307 | 0.89 | KDM4C (0.54) | KDM4CKDM5BKDM5AKDM2BKDM5C | |
| SCHEMBL18360339 | 0.89 | KLKB1 (0.42) | KDM4CKDM5BKDM5AKDM2BKLKB1 | |
| SCHEMBL16880891 | 0.86 | KLKB1 (0.45) | KLKB1KLK1KEAP1NFE2L2 | |
| SCHEMBL16891520 | 0.83 | KDM4C (0.42) | KDM4CKDM5BKDM5AKDM2BKDM5C | |
| SCHEMBL16891444 | 0.83 | KLKB1 (0.42) | KLKB1KLK1KEAP1NFE2L2 | |
| SCHEMBL21292976 | 0.83 | KDM4C (0.41) | KDM4CKDM5BKDM5AKDM2BKDM5C | |
| SCHEMBL16880479 | 0.82 | KLKB1 (0.46) | KDM4CKDM5BKDM5AKDM2BKDM5C | |
| SCHEMBL27925527 | 0.80 | KDM4C (0.62) | KDM4CKDM5BKDM5AKDM2BKDM5C | |
| SCHEMBL28105676 | 0.80 | KMT2A (0.49) | KLKB1KLK1MEN1KMT2A | |
| SCHEMBL28379113 | 0.80 | KLKB1 (0.43) | KLKB1KLK1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061480-B | Therapeutic inhibitory compounds | 莱福斯希医药公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-106061480-A | Therapeutic inhibitory compounds | 莱福斯希医药公司 | 2016-10-26 | — | — | CN | disclosed |