SCHEMBL27925527

SCHEMBL27925527

O=C(O)c1ccnc(Cc2ccccc2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 14/20 0.62
KDM5B Q9UGL1 12/20 0.62
KDM5A P29375 11/20 0.62
KDM2B Q8NHM5 2/20 0.62
KDM5C P41229 6/20 0.51
KDM4A O75164 5/20 0.51
KDM4E B2RXH2 4/20 0.51
KDM6B O15054 3/20 0.51
KDM2A Q9Y2K7 3/20 0.51
KDM3A Q9Y4C1 3/20 0.51
KDM4B O94953 1/20 0.51
TET3 O43151 1/20 0.50
BBOX1 O75936 1/20 0.50
ALDH1A1 P00352 1/20 0.50
MAPT P10636 1/20 0.50
ASPH Q12797 1/20 0.50
KDM4D Q6B0I6 1/20 0.50
TET2 Q6N021 1/20 0.50
ALKBH5 Q6P6C2 1/20 0.50
KDM7A Q6ZMT4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1569193 0.87 BRD4 (0.55) KDM4CKDM5BKDM5AKDM2BKDM5C
SCHEMBL27542831 0.85 KDM4C (0.63) KDM4CKDM5BKDM5AKDM2BKDM5C
SCHEMBL2996936 0.84 KDM5B (0.50) KDM4CKDM5BKDM5AKDM2BKDM5C
Hydrochloric Acid SCHEMBL30523486 0.83 KDM4C (0.61) KDM4CKDM5BKDM5AKDM2BKDM5C
SCHEMBL580585 0.83 KDM5B (0.56) KDM4CKDM5BKDM5AKDM2BKDM5C
SCHEMBL9517033 0.81 KDM4C (0.52) KDM4CKDM5BKDM5AKDM2BKDM5C
SCHEMBL28375280 0.80 KDM4C (0.53) KDM4CKDM5BKDM5AKDM2BKDM5C
SCHEMBL16535337 0.80 CYP1A2 (0.61) KDM4CKDM5BKDM5AKDM2BKDM5C
SCHEMBL4112733 0.79 TRPA1 (0.44) KDM4CKDM5BKDM5AKDM2BKDM5C
SCHEMBL18906030 0.79 FOLH1 (0.51) KDM4CKDM5BKDM5AKDM2BKDM5C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105685064-A HERBICIDAL ISOXAZOLO[5,4-b]PYRIDINES 巴斯夫欧洲公司 2016-06-22 CN claimed
CN-103124733-B Herbicidal isoxazolo [5,4-b ] pyridines BASF SE (DE) 2016-03-30 CN claimed
CN-103124733-A Herbicidal isoxazolo [5,4-b ] pyridines BASF SE 2013-05-29 CN claimed
CN-105685064-B Weeding isoxazoles simultaneously [5,4-b] pyridine 巴斯夫欧洲公司 2018-06-22 CN disclosed
CN-105685064-A HERBICIDAL ISOXAZOLO[5,4-b]PYRIDINES 巴斯夫欧洲公司 2016-06-22 CN disclosed
CN-103124733-B Herbicidal isoxazolo [5,4-b ] pyridines BASF SE (DE) 2016-03-30 CN disclosed
CN-103124733-A Herbicidal isoxazolo [5,4-b ] pyridines BASF SE 2013-05-29 CN disclosed