Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL28908418 | 1.00 | MEN1 (0.61) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL29976879 | 0.95 | MEN1 (0.64) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL1520018 | 0.80 | ALDH1A1 (0.61) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL13273820 | 0.78 | PIK3CD (0.43) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL29963500 | 0.76 | GAA (1.00) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL2762197 | 0.76 | GAA (1.00) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL20473696 | 0.74 | KMT2A (0.40) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL20473692 | 0.74 | ALDH1A1 (0.50) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL17202882 | 0.72 | POLB (0.41) | MEN1KMT2APOLBGAAMAPK1 | |
| SCHEMBL9053384 | 0.72 | KMT2A (0.86) | MEN1KMT2APOLBGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478558-A | Enantiomer-pure tetrahydrofuran spiro-oxoindole derivative and preparation method and application thereof | 郑州大学 | 2022-05-13 | — | — | CN | claimed |
| CN-108373473-B | Oxidized indole spiro tetrahydrofuran fluoride and crystal thereof, and preparation method and application thereof | 成都大学 | 2021-03-12 | — | — | CN | claimed |
| CN-108084201-B | Oxoindolspirotetrahydrofuran skeleton material, crystal thereof and preparation method thereof | 成都大学 | 2020-07-31 | — | — | CN | claimed |
| CN-108033969-B | Oxoindolspirotetrahydrofuran compound and preparation method and application thereof | 中国医药集团总公司四川抗菌素工业研究所 | 2020-04-10 | — | — | CN | claimed |
| CN-115340495-A | O-nitrobenzene compound and preparation method and application thereof | 华东理工大学 | 2022-11-15 | — | — | CN | disclosed |
| CN-114478558-A | Enantiomer-pure tetrahydrofuran spiro-oxoindole derivative and preparation method and application thereof | 郑州大学 | 2022-05-13 | — | — | CN | disclosed |
| CN-108373473-B | Oxidized indole spiro tetrahydrofuran fluoride and crystal thereof, and preparation method and application thereof | 成都大学 | 2021-03-12 | — | — | CN | disclosed |
| CN-108084201-B | Oxoindolspirotetrahydrofuran skeleton material, crystal thereof and preparation method thereof | 成都大学 | 2020-07-31 | — | — | CN | disclosed |
| CN-108084201-B | Oxoindolspirotetrahydrofuran skeleton material, crystal thereof and preparation method thereof | 成都大学 | 2020-07-31 | — | — | CN | disclosed |
| CN-108033969-B | Oxoindolspirotetrahydrofuran compound and preparation method and application thereof | 中国医药集团总公司四川抗菌素工业研究所 | 2020-04-10 | — | — | CN | disclosed |
| CN-108033969-B | Oxoindolspirotetrahydrofuran compound and preparation method and application thereof | 中国医药集团总公司四川抗菌素工业研究所 | 2020-04-10 | — | — | CN | disclosed |