Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.56 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.56 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857308 | 0.85 | NPC1 (0.57) | POLBCYP2C19PDK1PDK2PDK3 | |
| SCHEMBL505353 | 0.85 | CYP2C19 (0.69) | POLBCYP2C19PDK1PDK2PDK3 | |
| SCHEMBL29808973 | 0.85 | CYP2C19 (0.69) | POLBCYP2C19PDK1PDK2PDK3 | |
| SCHEMBL14397793 | 0.84 | CYP2C19 (0.58) | POLBCYP2C19PDK1PDK2PDK3 | |
| SCHEMBL27644581 | 0.83 | PDK1 (0.56) | POLBCYP2C19PDK1PDK2PDK3 | |
| SCHEMBL2943260 | 0.83 | PDK1 (0.56) | POLBCYP2C19PDK1PDK2PDK3 | |
| SCHEMBL211260 | 0.83 | KMT2A (0.61) | POLBALDH1A1L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL15233661 | 0.82 | POLB (0.62) | POLBHPGDALDH1A1KDM4ERAB9A | |
| SCHEMBL16127718 | 0.82 | CA12 (0.60) | POLBCYP2C19HPGDALDH1A1L3MBTL1 | |
| SCHEMBL28879810 | 0.82 | PDK1 (0.54) | POLBCYP2C19PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593079-B1 | MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES | SYMRISE AG (DE) | 2016-11-16 | — | — | EP | disclosed |
| US-9060949-B2 | Menthyl carbamate compounds as skin and/or hair lightening actives | SYMRISE AG (DE) | 2015-06-23 | — | — | US | disclosed |
| US-20130129646-A1 | MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES | SYMRISE AG (DE) | 2013-05-23 | — | — | US | disclosed |
| EP-2593079-A2 | MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES | Symrise AG (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010097480-A2 | MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES | SYMRISE GMBH & CO. KG (DE) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010089421-A2 | MENTHYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS | SYMRISE GMBH & CO. KG (DE) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130129646-A1 | MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES | TYR, CRAT, SUCLG1 | POLB 1100/4885CYP2C19 222/4885PDK1 1888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.