SCHEMBL2837784

SCHEMBL2837784

NC[C@H]1CN(c2ccc(OCc3ccccc3)c(F)c2)C(=O)O1

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 5/20 0.47
CALML3 P27482 4/20 0.47
S1PR5 Q9H228 1/20 0.46
F10 P00742 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17769261 0.89 GRM2 (0.47) GRM2CALML3S1PR5
SCHEMBL17769259 0.89 GRM2 (0.47) GRM2CALML3S1PR5
SCHEMBL541807 0.89 CALML3 (0.59) GRM2CALML3S1PR5
SCHEMBL9611100 0.89 GRM2 (0.49) GRM2CALML3S1PR5
SCHEMBL541806 0.89 CALML3 (0.59) GRM2CALML3S1PR5
SCHEMBL3205152 0.88 GRM2 (0.48) GRM2CALML3S1PR5F10
SCHEMBL18202919 0.85 GRM2 (0.49) GRM2CALML3S1PR5
SCHEMBL13581450 0.84 CALML3 (0.43) GRM2CALML3S1PR5
SCHEMBL2848392 0.84 GRM2 (0.47) GRM2CALML3S1PR5
SCHEMBL17769268 0.84 GRM2 (0.47) GRM2CALML3S1PR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2256120-A1 Oxazolidinone-quinolone hybrids as antibacterial compounds Actelion Pharmaceuticals Ltd. (CH) 2010-12-01 EP disclosed
US-20100222302-A1 Novel Antibacterial Compounds ACTELION PHARMACEUTICALS LTD (CH) 2010-09-02 US disclosed
EP-1931684-A2 OXAZOLIDINONE-QUINOLONE HYBRIDS AS ANTIBACTERIAL COMPOUNDS Actelion Pharmaceuticals Ltd. (CH) 2008-06-18 EP disclosed
WO-2007017828-A2 OXAZOLIDINONE-QUINOLONE HYBRIDS AS ANTIBACTERIAL COMPOUNDS ACTELION PHARMACEUTICALS LTD (CH) 2007-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222302-A1 Novel Antibacterial Compounds ODC1, AOC1, OGFOD1 GRM2 2313/4885CALML3 2993/4885S1PR5 3309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.