Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 5/20 | 0.52 |
| ▸ | CTSK | P43235 | 5/20 | 0.52 |
| ▸ | ACE | P12821 | 2/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013449 | 1.00 | HDAC3 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29633813 | 1.00 | HDAC3 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2837978 | 1.00 | HDAC3 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29809224 | 1.00 | HDAC3 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL23587982 | 0.96 | IDO1 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18396013 | 0.96 | IDO1 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL23677933 | 0.96 | IDO1 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL24445141 | 0.92 | ACE (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18394929 | 0.92 | ACE (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18396391 | 0.92 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109438321-B | Tryptophan derivative and preparation method and application thereof | 南京友怡医药科技有限公司 | 2021-12-17 | — | — | CN | claimed |
| CN-109438321-A | A kind of tryptophan derivative and its preparation method and application | 南京友怡医药科技有限公司 | 2019-03-08 | — | — | CN | claimed |
| US-20240209010-A1 | PRODRUGS OF AZO COMPOUNDS AND THEIR SALTS | AMNEAL PHARMACEUTICALS LLC | 2024-06-27 | — | — | US | disclosed |
| EP-4297755-A1 | PRODRUGS OF AZO COMPOUNDS AND THEIR SALTS | Kashiv Biosciences, LLC (US) | 2024-01-03 | — | — | EP | disclosed |
| CN-117337181-A | Prodrugs of azo compounds and salts thereof | 卡希夫生物科学有限公司 | 2024-01-02 | — | — | CN | disclosed |
| WO-2023211930-A1 | DUAL FUNCTIONING IMMUNE MODULATING COMPOUNDS, FORMULATIONS, AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-11-02 | — | — | WO | disclosed |
| US-20230036412-A1 | PEGYLATED ICD INDUCER-IDO INHIBITOR NANOCONJUGATE, AND PREPARATION METHOD AND USE THEREOF | SHANDONG UNIVERSITY (CN) | 2023-02-02 | — | — | US | disclosed |
| EP-3954369-A1 | SALTS AND PRODRUGS OF 1-METHYL-D-TRYPTOPHAN | Lumos Pharma, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-109438321-B | Tryptophan derivative and preparation method and application thereof | 南京友怡医药科技有限公司 | 2021-12-17 | — | — | CN | disclosed |
| EP-3324958-B1 | SALTS AND PRODRUGS OF 1-METHYL-D-TRYPTOPHAN | LUMOS PHARMA INC (US) | 2021-07-28 | — | — | EP | disclosed |
| CN-109438321-A | A kind of tryptophan derivative and its preparation method and application | 南京友怡医药科技有限公司 | 2019-03-08 | — | — | CN | disclosed |
| EP-2152664-A1 | DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS | Brystol-Myers Squibb Company (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008157162-A1 | DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-24 | — | — | WO | disclosed |
| CN-101094861-A | Agonists and antagonists of the somatostatin receptor | NOVARTIS AG (CH) | 2007-12-26 | — | — | CN | disclosed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
| EP-1200432-B1 | AMIDO SPIROPIPERIDINES PROMOTE THE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2004-05-12 | — | — | EP | disclosed |
| EP-1200432-A4 | AMIDO SPIROPIPERIDINES PROMOTE THE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6420376-B1 | Amido spiropiperidines promote the release of growth hormone | MERCK & CO., INC. | 2002-07-16 | — | — | US | disclosed |
| EP-1200432-A1 | AMIDO SPIROPIPERIDINES PROMOTE THE RELEASE OF GROWTH HORMONE | Merck & Co., Inc. (US) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004119-A1 | AMIDO SPIROPIPERIDINES PROMOTE THE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 2001-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | HDAC3 2/4885HDAC4 7/4885HDAC1 1/4885 |
| US-20240209010-A1 | PRODRUGS OF AZO COMPOUNDS AND THEIR SALTS | CYP11B1, CYP2C19, CYP11B2 | HDAC3 951/4885HDAC4 1144/4885HDAC1 655/4885 |
| US-20230036412-A1 | PEGYLATED ICD INDUCER-IDO INHIBITOR NANOCONJUGATE, AND PREPARATION METHOD AND USE THEREOF | IDO1, IDO2, CD274 | HDAC3 3140/4885HDAC4 4268/4885HDAC1 2408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.