Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Furosemide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 8/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | CA12 | O43570 | 2/20 | 0.98 |
| ▸ | CA1 | P00915 | 2/20 | 0.98 |
| ▸ | CA2 | P00918 | 2/20 | 0.98 |
| ▸ | CA6 | P23280 | 2/20 | 0.98 |
| ▸ | CA5A | P35218 | 2/20 | 0.98 |
| ▸ | CA7 | P43166 | 2/20 | 0.98 |
| ▸ | CA9 | Q16790 | 2/20 | 0.98 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.98 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | CA4 | P22748 | 1/20 | 0.98 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.98 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.98 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.98 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.98 |
| ▸ | APP | P05067 | 9/20 | 0.75 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furosemide SCHEMBL29406913 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL428921 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL9811 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL2953945 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL10867860 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL6751172 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL4308371 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL2519788 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL1109955 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL8392126 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105562867-B | A kind of intravascular Nitinol seal wire, seal wire welding tooling and seal wire welding method | 深圳麦普奇医疗科技有限公司 | 2018-04-06 | — | — | CN | claimed |
| CN-205380335-U | Nickel titanium alloy seal wire in blood vessel and welding frock thereof | 深圳麦普奇医疗科技有限公司 | 2016-07-13 | — | — | CN | claimed |
| CN-105562867-A | Nickel-titanium alloy guiding wire in vessel, guiding wire welding tool and guiding wire welding method | SHENZHEN MAIPUQI MEDICAL TECH CO LTD | 2016-05-11 | — | — | CN | claimed |
| CN-105562867-B | A kind of intravascular Nitinol seal wire, seal wire welding tooling and seal wire welding method | 深圳麦普奇医疗科技有限公司 | 2018-04-06 | — | — | CN | disclosed |
| CN-106902611-A | Gas purifying device | 日本派欧尼株式会社 | 2017-06-30 | — | — | CN | disclosed |
| US-9653270-B2 | Method for connecting magnetic substance target to backing plate, and magnetic substance target | JX NIPPON MINING & METALS CORPORATION (JP) | 2017-05-16 | — | — | US | disclosed |
| CN-205380335-U | Nickel titanium alloy seal wire in blood vessel and welding frock thereof | 深圳麦普奇医疗科技有限公司 | 2016-07-13 | — | — | CN | disclosed |
| CN-105715798-A | Sealing gasket | 日本派欧尼株式会社 | 2016-06-29 | — | — | CN | disclosed |
| CN-105562867-A | Nickel-titanium alloy guiding wire in vessel, guiding wire welding tool and guiding wire welding method | SHENZHEN MAIPUQI MEDICAL TECH CO LTD | 2016-05-11 | — | — | CN | disclosed |
| CN-105540541-A | Method for refining hydrogen | JAPAN PIONICS | 2016-05-04 | — | — | CN | disclosed |
| CN-104925756-A | Hydrogen purifying device and hydrogen purifying system employing the same | JAPAN PIONICS | 2015-09-23 | — | — | CN | disclosed |
| US-20090008245-A1 | Method for Connecting Magnetic Substance Target to Backing Plate, and Magnetic Substance Target | NIPPON MINING & METALS CO., LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| CN-100396812-C | Method for connecting magnetic target and backing plate, and magnetic target | NIKKO MATERIALS CO LTD (JP) | 2008-06-25 | — | — | CN | disclosed |
| US-7347353-B2 | Method for connecting magnetic substance target to backing plate, and magnetic substance target | NIPPON MINING & METALS CO., LTD. (JP) | 2008-03-25 | — | — | US | disclosed |
| US-20060137782-A1 | Target of high-purity nickel or nickel alloy and its producing method | NIKKO MATERIALS CO., LTD. (JP) | 2006-06-29 | — | — | US | disclosed |
| CN-1606633-A | Method for connecting magnetic target and backing plate, and magnetic target | NIKKO MATERIALS CO LTD (JP) | 2005-04-13 | — | — | CN | disclosed |
| US-20040265616-A1 | Method for connecting magnetic substance target to backing plate, and magnetic substance target | JX NIPPON MINING & METALS CORPORATION (JP) | 2004-12-30 | — | — | US | disclosed |
| US-20040256035-A1 | Target of high-purity nickel or nickel alloy and its producing method | JX NIPPON MINING & METALS CORPORATION (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1466999-A1 | METHOD FOR CONNECTING MAGNETIC SUBSTANCE TARGET TO BACKING PLATE AND MAGNETIC SUBSTANCE TARGET | Nikko Materials Company, Limited (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1467000-A1 | TARGET OF HIGH-PURITY NICKEL OR NICKEL ALLOY AND ITS PRODUCING METHOD | Nikko Materials Company, Limited (JP) | 2004-10-13 | — | — | EP | disclosed |