Furosemide

Furosemide

SCHEMBL29406913

NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC12A1

The experimentally established mechanism targets of Furosemide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CISD1 Q9NZ45 8/20 1.00
ALDH1A1 P00352 2/20 1.00
CA12 O43570 2/20 1.00
CA1 P00915 2/20 1.00
CA2 P00918 2/20 1.00
CA6 P23280 2/20 1.00
CA5A P35218 2/20 1.00
CA7 P43166 2/20 1.00
CA9 Q16790 2/20 1.00
CA14 Q9ULX7 2/20 1.00
CA5B Q9Y2D0 2/20 1.00
HTR1A P08908 1/20 1.00
CA4 P22748 1/20 1.00
HSD11B1 P28845 1/20 1.00
SLC10A1 Q14973 1/20 1.00
GPR35 Q9HC97 1/20 1.00
ABCG2 Q9UNQ0 1/20 1.00
APP P05067 9/20 0.77
TEX264 Q9Y6I9 1/20 0.67
POLB P06746 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Furosemide SCHEMBL9811 1.00 CISD1 (1.00) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL428921 1.00 CISD1 (1.00) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL11319593 0.99 CISD1 (0.98) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL10867860 0.99 CISD1 (0.98) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL8092440 0.99 CISD1 (0.98) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL10339959 0.99 CISD1 (0.98) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL2953945 0.99 CISD1 (0.98) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL1109955 0.99 CISD1 (0.98) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL2519788 0.99 CISD1 (0.98) CISD1ALDH1A1CA12CA1CA2
Furosemide SCHEMBL6751172 0.99 CISD1 (0.98) CISD1ALDH1A1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113271923-B Pharmaceutical composition of furosemide and application thereof SQ创新股份公司 2025-05-13 CN claimed
US-20250043174-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE COMPRISING SAME BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2025-02-06 US claimed
US-20240368465-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE COMPRISING SAME Beijing Summer Sprout Technology Co., Ltd. (CN) 2024-11-07 US claimed
US-11903305-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2024-02-13 US claimed
US-11711969-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-07-25 US claimed
EP-4023218-A1 COMBINATION THERAPY FOR PATIENTS HAVING ACUTE AND/OR PERSISTENT DYSPNEA S-Form Pharma (BE) 2022-07-06 EP claimed
US-20260144782-A1 METHODS FOR THE TREATMENT OF ABNORMAL INVOLUNTARY MOVEMENT DISORDERS AUSPEX PHARMACEUTICALS LLC (US) 2026-05-28 US disclosed
CN-114401960-B Glue degradation agent and using method thereof NOVARTIS AG (CH) 2026-05-26 CN disclosed
US-20260137673-A1 METHODS FOR THE TREATMENT OF ABNORMAL INVOLUNTARY MOVEMENT DISORDERS AUSPEX PHARMACEUTICALS LLC (US) 2026-05-21 US disclosed
EP-3773730-B1 DRUG DELIVERY FORMULATIONS UNIV CALIFORNIA (US) 2026-05-13 EP disclosed
US-20260115134-A1 NOVEL PHARMACEUTICAL FORMULATIONS AUSPEX PHARMACEUTICALS INC (US) 2026-04-30 US disclosed
US-20260115135-A1 NOVEL PHARMACEUTICAL FORMULATIONS AUSPEX PHARMACEUTICALS INC (US) 2026-04-30 US disclosed
US-20260115148-A1 HOMEOPATHIC THERAPEUTIC METHOD AND COMPOSITIONS CEARNA INC (US) 2026-04-30 US disclosed
US-20220071935-A1 BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE NEUROPRO THERAPEUTICS, INC. 2022-03-10 US disclosed
US-20220072023-A1 COMPOSITIONS AND METHODS FOR METAL CONTAINING FORMULATIONS CAPABLE OF MODULATING IMMUNE RESPONSE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-03-10 US disclosed
US-20220072131-A1 Dihydroxyphenyl Neurotransmitter Compounds, Compositions And Methods AUSPEX PHARMACEUTICALS INC (US) 2022-03-10 US disclosed
EP-3962455-A1 NEW PHARMACEUTICAL COMPOSITION FOR DRUG DELIVERY Orexo AB (SE) 2022-03-09 EP disclosed
US-11260127-B2 Mesoporous silica nanoparticles for diagnostic and therapeutic applications CASE WESTERN RESERVE UNIVERSITY (US) 2022-03-01 US disclosed
US-11260058-B2 Compositions and method of treating cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-01 US disclosed
CN-114010632-A Enalapril maleate and furosemide compound tablet and preparation method and application thereof 上海汉维生物医药科技有限公司 2022-02-08 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260144782-A1 METHODS FOR THE TREATMENT OF ABNORMAL INVOLUNTARY MOVEMENT DISORDERS DRD2, HTR2C, SLC18A2 CISD1 1076/4885ALDH1A1 2019/4885CA12 4147/4885
US-11711969-B2 Organic electroluminescent materials and devices RPS4X, NCOA4, KCNN4 CISD1 4072/4885ALDH1A1 3044/4885CA12 1208/4885
US-20220072023-A1 COMPOSITIONS AND METHODS FOR METAL CONTAINING FORMULATIONS CAPABLE OF MODULATING IMMUNE RESPONSE MYD88, STING1, TLR3 CISD1 1663/4885ALDH1A1 4001/4885CA12 655/4885
US-20220072131-A1 Dihydroxyphenyl Neurotransmitter Compounds, Compositions And Methods SLC18A2, COMT, SLC6A2 CISD1 4250/4885ALDH1A1 1234/4885CA12 2298/4885
US-20220071935-A1 BUMETANIDE ANALOGS, COMPOSITIONS AND METHODS OF USE SLC6A1, SLC6A13, SLC6A11 CISD1 3650/4885ALDH1A1 835/4885CA12 1338/4885
US-11260058-B2 Compositions and method of treating cancer TP53, HCCS, TOP2A CISD1 4067/4885ALDH1A1 2183/4885CA12 104/4885
US-20260115134-A1 NOVEL PHARMACEUTICAL FORMULATIONS HTR1D, HTR5A, PCNP CISD1 1194/4885ALDH1A1 1593/4885CA12 4532/4885
US-11903305-B2 Organic electroluminescent materials and devices OGFRL1, OPRM1, OSBP CISD1 459/4885ALDH1A1 801/4885CA12 3157/4885
US-20260115148-A1 HOMEOPATHIC THERAPEUTIC METHOD AND COMPOSITIONS HIRA, GJA1, CD44 CISD1 2500/4885ALDH1A1 1050/4885CA12 778/4885
US-20260115135-A1 NOVEL PHARMACEUTICAL FORMULATIONS FLNB, SETD1B, HTR5A CISD1 1598/4885ALDH1A1 2033/4885CA12 3489/4885
US-20260137673-A1 METHODS FOR THE TREATMENT OF ABNORMAL INVOLUNTARY MOVEMENT DISORDERS HTT, HTR2C, NSD1 CISD1 651/4885ALDH1A1 2310/4885CA12 4065/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.