Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Furosemide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 1.00 |
| ▸ | CA1 | P00915 | 2/20 | 1.00 |
| ▸ | CA2 | P00918 | 2/20 | 1.00 |
| ▸ | CA6 | P23280 | 2/20 | 1.00 |
| ▸ | CA5A | P35218 | 2/20 | 1.00 |
| ▸ | CA7 | P43166 | 2/20 | 1.00 |
| ▸ | CA9 | Q16790 | 2/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | CA4 | P22748 | 1/20 | 1.00 |
| ▸ | HSD11B1 | P28845 | 1/20 | 1.00 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 1.00 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 1.00 |
| ▸ | APP | P05067 | 9/20 | 0.77 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furosemide SCHEMBL29406913 | 1.00 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL428921 | 1.00 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL11319593 | 0.99 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL10867860 | 0.99 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL8092440 | 0.99 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL10339959 | 0.99 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL2953945 | 0.99 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL1109955 | 0.99 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL2519788 | 0.99 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL6751172 | 0.99 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 268163 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| CN-122075467-A | Application of medicine in preventing or treating hydrocephalus | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| EP-4739290-A1 | LYOPHILIZED METOLAZONE FORMULATION FOR PARENTERAL ADMINISTRATION | Hyloris Developments SA (BE) | 2026-05-13 | — | — | EP | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| WO-2026090360-A1 | FUSED PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC. (US) | 2026-04-30 | — | — | WO | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| WO-2026087695-A1 | TREATMENT FOR METABOLIC DISORDER | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| EP-3934654-B1 | ISTAROXIME OR ITS METABOLITE PST-3093 FOR USE AS INTRAVENOUS FORMULATION FOR THE TREATMENT OF ACUTE HEART FAILURE (AHF) | WINDTREE THERAPEUTICS INC (US) | 2026-04-29 | — | — | EP | claimed |
| US-20260108529-A1 | FUSED AMINO PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, AGE-RELATED HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC (US) | 2026-04-23 | — | — | US | claimed |
| US-4055259-A | Sample transport with rotary air interlock charging and discharging means | THE PERKIN-ELMER CORPORATION (US) | 1977-10-25 | — | — | US | claimed |
| US-4033113-A | Steam generation with coal | CLEAN ENERGY CORPORATION (US) | 1977-07-05 | — | — | US | claimed |
| US-4029776-A | MITIGATING SECONDARY ALDOSTERONISM AND POTASSIUM DEPLETION INDUCED BY DIURETIC THERAPY | STERLING DRUG INC. (US) | 1977-06-14 | — | — | US | claimed |
| US-RE29095-E | Take-up spool latch | Rainsfords Metal Products Proprietary Ltd. (AU) | 1977-01-04 | — | — | US | claimed |
| US-3997923-A | Heart valve prosthesis and suturing assembly and method of implanting a heart valve prosthesis in a heart | ST. JUDE MEDICAL, INC. (US) | 1976-12-21 | — | — | US | claimed |
| US-3990590-A | Device for collecting materials in bulk inside a tank | ZOMPETTA ANTONIO | 1976-11-09 | — | — | US | claimed |
| US-3966582-A | HYDROGENATION, MOLTEN INORGANIC SALTS | CLEAN ENERGY CORPORATION (US) | 1976-06-29 | — | — | US | claimed |
| US-3956477-A | STROMA, BUFFERS, BACTERICIDES | AKZONA INCORPORATED (US) | 1976-05-11 | — | — | US | claimed |
| US-3939713-A | Septum mounting and shielding assembly for sample injection in an analytical instrument | THE PERKIN-ELMER CORPORATION (US) | 1976-02-24 | — | — | US | claimed |
| US-3933128-A | DISSOLVING FUEL IN MOLTEN SALT | CLEAN ENERGY CORPORATION (US) | 1976-01-20 | — | — | US | claimed |