Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28382355 | 0.91 | PIM1 (0.34) | PIM1PIM2 | |
| SCHEMBL28887739 | 0.88 | EGFR (0.52) | JAK2FGFR1KDREGFRFGFR2 | |
| SCHEMBL28383435 | 0.86 | JAK2 (0.47) | JAK2BRD4 | |
| SCHEMBL28388175 | 0.85 | MAP4K1 (0.43) | JAK2BRD4FGFR1KDREGFR | |
| SCHEMBL28383253 | 0.85 | JAK2 (0.44) | JAK2BRD4 | |
| SCHEMBL28070382 | 0.84 | TTK (0.45) | TTK | |
| SCHEMBL28383448 | 0.84 | EGFR (0.42) | JAK2BRD4FGFR1KDREGFR | |
| SCHEMBL28070380 | 0.84 | TTK (0.41) | TTK | |
| SCHEMBL28382399 | 0.84 | CHEK1 (0.40) | — | |
| SCHEMBL28070373 | 0.84 | MAPK10 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | claimed |
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111285813-A | Chemical entities, compositions, and methods | 润新生物公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | disclosed |