Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 9/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28266286 | 0.84 | RXRA (0.38) | KCNH2RXRAGRIN1GRIN2B | |
| SCHEMBL28266301 | 0.80 | GRIN1 (0.45) | KCNH2RXRAGRIN1GRIN2B | |
| SCHEMBL28266364 | 0.76 | GRIN1 (0.50) | KCNH2RXRAGRIN1GRIN2B | |
| SCHEMBL28266353 | 0.75 | RXRA (0.43) | KCNH2RXRAGRIN1GRIN2B | |
| SCHEMBL28719969 | 0.75 | KCNH2 (0.39) | KCNH2IDO1TDO2NOTUMPDE4B | |
| SCHEMBL15657033 | 0.74 | NOTUM (0.47) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL4311390 | 0.74 | NOTUM (0.47) | KCNH2NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL28266344 | 0.74 | RXRA (0.44) | RXRAGRIN1GRIN2B | |
| SCHEMBL27786776 | 0.72 | KEAP1 (0.53) | KCNH2IDO1TDO2NOTUMRXRA | |
| SCHEMBL27786788 | 0.72 | NOTUM (0.53) | IDO1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239937-A | Compounds, compositions, and methods | 戴纳立制药公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-118239938-A | Compounds, compositions, and methods | 戴纳立制药公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-111094233-B | Compounds, compositions, and methods | 戴纳立制药公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-117580824-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-114206848-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-111094233-A | Compounds, compositions and methods | 戴纳立制药公司 | 2020-05-01 | — | — | CN | disclosed |